The Knoxville Register was an American newspaper published primarily in Knoxville, Tennessee, during the 19th century. Founded in 1816, the paper was East Tennessee's dominant newspaper until 1863, when its pro-secession editor, Jacob Austin Sperry (1823–1896), was forced to flee advancing Union forces at the height of the Civil War. Sperry continued to sporadically publish the Register in Atlanta, and later Bristol, until he was finally captured by Union forces in December 1864.