Frederick Steidinger Heiskell (1786 – November 29, 1882) was an American newspaper publisher, politician, and civic leader, active primarily in Knoxville, Tennessee, throughout much of the 19th century. He cofounded the Knoxville Register, which during its early years was the city's only newspaper, and operated a printing firm that published a number of early important books on Tennessee history and law. He also served one term in the Tennessee Senate (1847–1849), and briefly served as Mayor of Knoxville in 1835. He was a trustee, organizer, or financial supporter of numerous schools and civic organizations.