The West Branch Susquehanna Valley of central Pennsylvania, United States, in the Ridge-and-valley Appalachians, is the low-lying area draining into the West Branch Susquehanna River southeast of the Allegheny Front, northeast of the Bald Eagle Valley, southwest of the Wyoming Valley and north of the water gap formed between and . In Clinton and Lycoming Counties, it is northeast of the Bald Eagle Valley and runs from Lock Haven to Williamsport.