Margaret Jean "Margo" St. James (September 12, 1937 – January 11, 2021) was an American prostitute and sex-positive feminist. In San Francisco, she founded COYOTE (Call Off Your Old Tired Ethics), an organization advocating decriminalization of prostitution, and co-founded the St. James Infirmary Clinic, a medical and social service organization serving sex workers in the Tenderloin.