David Leslie (1797 – March 1, 1869) was an American missionary and pioneer in what became the state of Oregon. A native of New Hampshire, he joined Jason Lee as a missionary at the Methodist Mission in the Oregon Country in 1836. In that region he participated in the early movement to start a government and his home was used for some of these meetings. With the closing of the mission he became a founder of the city of Salem, Oregon, and board member of the Oregon Institute, which later became Willamette University.