Cairo Rail Bridge is the name of two bridges crossing the Ohio River near Cairo, Illinois in the United States. The original was an 1889 George S. Morison through-truss and deck truss bridge, replaced by the current bridge in 1952. The second and current bridge is a through-truss bridge that reused many of the original bridge piers. As of 2018, trains like the City of New Orleans travel over the Ohio River supported by the same piers whose construction began in 1887.