The 2005–06 St. Louis Blues season was the 39th for the franchise in St. Louis, Missouri, and the first since the 2004–05 NHL lockout. The Blues finished the regular season with a record of 21 wins, 46 losses and 15 losses in overtime, sufficient for an NHL season-low of 57 points. The Blues failed to qualify for the Stanley Cup playoffs for the first time since the 1978–79 season, ending their streak of consecutive playoff appearances at 25 seasons.