The Col. Frank J. Hecker House is a historic home in Detroit built in 1888 for local businessman and railroad-car manufacturer Colonel Frank J. Hecker. Located at 5510 Woodward Avenue, it was designated a Michigan State Historic Site in 1958. It is located near to the East Ferry Avenue Historic District and Cultural Center Historic District, and was listed on the National Register of Historic Places in 1971. The house has been owned by Wayne State University since September 2014.