The 2005–06 Michigan State Spartans men's basketball team represented Michigan State University in the 2005–06 NCAA Division I men's basketball season. Their head coach was Tom Izzo, who was in his 11th year at Michigan State. The team played its home games at Breslin Center in East Lansing, Michigan, and competed in the Big Ten Conference. MSU finished the season with a record of 22–12, 8–8 in Big Ten play to finish in a tie for sixth place. As the No. 6 seed in the Big Ten tournament, they defeated Purdue and Illinois before losing to Iowa in the semifinals. They received an at-large bid to the NCAA tournament as the No. 6 seed in the Washington D.C. bracket, marking the school's ninth consecutive trip to the NCAA Tournament under Izzo. They lost in the First Round to eventual Final Four