William Drayton (December 30, 1776 – May 24, 1846) was an American politician, banker, and writer who grew up in Charleston, South Carolina. He was the son of William Drayton Sr., who served as justice of the Province of East Florida (1765–1780). Drayton served as a United States Representative to Congress (1825–1833). Following the Nullification Crisis, as a unionist Drayton decided to move his family to Philadelphia, Pennsylvania in 1833 and lived there the rest of his life.