Route 66 is an American adventure crime drama television series that premiered on CBS on October 7, 1960, and ran until March 20, 1964, for a total of 116 episodes. The series was created by Herbert B. Leonard and Stirling Silliphant, who were also responsible for the ABC drama Naked City, from which Route 66 was an indirect spin-off. Both series employed a format with elements of both traditional drama and anthology drama, but the difference was where the shows were set: Naked City was set in New York City, while Route 66 had its setting change from week to week, with each episode being shot on location.