Rolf Huisgen (German: ['huːzgɛn]; 13 June 1920 – 26 March 2020) was a German chemist. His importance in synthetic organic chemistry extends to the enormous influence he had in post-war chemistry departments in Germany and Austria, due to a large number of his habilitants becoming professors. His major achievement was the development of the 1,3-dipolar cycloaddition reaction, also called the Huisgen cycloaddition.