Lewes (/luː.əs/ LOO-iss) is an incorporated city on the Delaware Bay in eastern Sussex County, Delaware, United States. According to the 2010 census, the population is 2,747. Along with neighboring Rehoboth Beach, Lewes is one of the principal cities of Delaware's rapidly growing Cape Region. The city lies within the Salisbury, Maryland–Delaware Metropolitan Statistical Area. Lewes proudly claims to be "The First Town in The First State."