Charles Anderson Wickliffe (June 8, 1788 – October 31, 1869) was a U.S. Representative from Kentucky. He also served as Speaker of the Kentucky House of Representatives, the 14th Governor of Kentucky, and was appointed Postmaster General by President John Tyler. Though he consistently identified with the Whig Party, he was politically independent, and often had differences of opinion with Whig founder and fellow Kentuckian Henry Clay.