Andy O'Brien (21 January 1915 – 4 December 2006) was a Fine Gael politician from County Cavan in Ireland. He was a senator from 1969 to 1982, and from 1983 to 1987. O'Brien was a teacher who served as principal of the national school in Crubany for more than 40 years. He was member of Cavan County Council and Cavan Urban District Council for over 40 years, and a leading organiser of Fine Gael in the county.