The 2010–11 Buffalo Bulls men's basketball team represented the University at Buffalo during the 2010–11 NCAA Division I men's basketball season. The Bulls, led by twelfth-year head coach Reggie Witherspoon, played their home games at Alumni Arena in Amherst, New York as members of the Mid-American Conference (MAC). They finished the season 20–14, 8–8 in MAC play to finish in sixth place in the MAC East. It was the third 20-win season in the school's NCAA Division I history and the second in their past three seasons.