U.S. Highway 12 (US 12) is a 192.798-mile-long (310.278 km) U.S. Highway in west-central and east-central Minnesota, which travels from the South Dakota state line at Ortonville near Big Stone Lake and continues east to the St. Croix River at the Wisconsin state line. US 12 connects the cities of Ortonville, Benson, Willmar, Litchfield, Minneapolis, and Saint Paul.