The Southern Terminal is a former railway complex located at 306 West Depot Avenue in Knoxville, Tennessee, USA. The complex, which includes a passenger terminal and express depot adjacent to a large railyard, was built in 1903 by the Southern Railway. Both the terminal and depot were designed by noted train station architect Frank Pierce Milburn (1868–1926). In 1985, the terminal complex, along with several dozen warehouses and storefronts in the adjacent Old City and vicinity, were listed on the National Register of Historic Places as the Southern Terminal and Warehouse Historic District.