South Central Pennsylvania is a region of the U.S. state of Pennsylvania that includes the fourteen counties of Adams, Cumberland, Dauphin, Franklin, Huntingdon, Juniata, Lancaster, Lebanon, Mifflin, Perry, Snyder, and York. Portions of western Schuylkill and southern Northumberland counties are also located in South Central Pennsylvania. Despite the designation "South Central Pennsylvania," many of the counties are geographically located in the southeastern portion of the state. Lancaster, with a population of 59,322, is the largest city in the region, and the second largest metropolitan area. Harrisburg, with a population of 49,528, is the second largest city in the region, and has the largest metropolitan area with a population of 643,820 people, and is the capital of Pennsylvania. York