Periventricular leukomalacia (PVL) is a form of white-matter brain injury, characterized by the necrosis (more often coagulation) of white matter near the lateral ventricles. It can affect newborns and (less commonly) fetuses; premature infants are at the greatest risk of neonatal encephalopathy which may lead to this condition. Affected individuals generally exhibit motor control problems or other developmental delays, and they often develop cerebral palsy or epilepsy later in life. The white matter in preterm born children is particularly vulnerable during the third trimester of pregnancy when white matter developing takes place and the myelination process starts around 30 weeks of gestational age.
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| - Periventrikuläre Leukomalazie (de)
- Leucomalacia periventricolare (it)
- 脳室周囲白質軟化症 (ja)
- Periventricular leukomalacia (en)
- Leucomalácia periventricular (pt)
- Перивентрикулярная лейкомаляция (ru)
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| - Unter einer periventrikulären Leukomalazie (PVL) (altgriechisch περί perí, deutsch ‚um, herum‘, lateinisch ventriculus ‚kleiner Bauch, Magen‘ sowie altgriechisch λευκός leukós, deutsch ‚weiß‘ und μαλακός malakós, deutsch ‚weich, zart‘) wird in der Medizin eine der häufigsten durch erheblichen Sauerstoffmangel verursachte Schädigung der weißen Substanz im Gehirn verstanden. Die PVL tritt besonders häufig bei frühgeborenen Kindern im Säuglingsalter auf. Der Begriff stammt von Banker & Larroche aus dem Jahre 1962. (de)
- 脳室周囲白質軟化症 (のうしつしゅういはくしつなんかしょう、periventricular leukomalacia, PVL) とは、早産児あるいは低出生体重児が来たしうる、脳室周囲の白質に軟化病巣が生じる疾患である。脳室周囲白質部、特に三角部には頭頂葉に存在する運動中枢からの神経線維、いわゆる皮質脊髄路が存在するため、PVL の存在する児ではその連絡が絶たれ、となる。 (ja)
- La leucomalacia periventricolare è il rammollimento patologico della sostanza cerebrale, cioè di una parte dell'encefalo funzionale alla trasmissione degli impulsi nervosi. (it)
- Leucomalacia periventricular (LPV) é uma forma de lesão cerebral, caracterizado por a necrose (mais frequentemente coagulação) da substancia branca perto dos ventrículos laterais. Ela pode afetar recém-nascidos e (menos comumente) fetos. Crianças prematuras estão em maior risco da doença. Os indivíduos afetados geralmente apresentam problemas no sistema motor ou outros atrasos de desenvolvimento. Podem desenvolver paralisia cerebral ou epilepsia mais tarde na vida. (pt)
- Перивентрикулярная лейкомаляция (ПВЛ) — форма поражения белого вещества полушарий головного мозга у детей, открытая морфологами, одна из причин детского церебрального паралича. ПВЛ характеризуется возникновением очагов некроза, преимущественно коагуляционного, в перивентрикулярных зонах белого вещества полушарий головного мозга у новорождённых детей (редко у мертворождённых). Она относится к одной из форм так называемой «гипоксически-ишемической энцефалопатии». (ru)
- Periventricular leukomalacia (PVL) is a form of white-matter brain injury, characterized by the necrosis (more often coagulation) of white matter near the lateral ventricles. It can affect newborns and (less commonly) fetuses; premature infants are at the greatest risk of neonatal encephalopathy which may lead to this condition. Affected individuals generally exhibit motor control problems or other developmental delays, and they often develop cerebral palsy or epilepsy later in life. The white matter in preterm born children is particularly vulnerable during the third trimester of pregnancy when white matter developing takes place and the myelination process starts around 30 weeks of gestational age. (en)
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| - Drawing of the lateral and third ventricles of the brain. Periventricular leukomalacia involves death of the white matter surrounding the lateral ventricles in fetuses and infants. (en)
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| - Unter einer periventrikulären Leukomalazie (PVL) (altgriechisch περί perí, deutsch ‚um, herum‘, lateinisch ventriculus ‚kleiner Bauch, Magen‘ sowie altgriechisch λευκός leukós, deutsch ‚weiß‘ und μαλακός malakós, deutsch ‚weich, zart‘) wird in der Medizin eine der häufigsten durch erheblichen Sauerstoffmangel verursachte Schädigung der weißen Substanz im Gehirn verstanden. Die PVL tritt besonders häufig bei frühgeborenen Kindern im Säuglingsalter auf. Der Begriff stammt von Banker & Larroche aus dem Jahre 1962. (de)
- Periventricular leukomalacia (PVL) is a form of white-matter brain injury, characterized by the necrosis (more often coagulation) of white matter near the lateral ventricles. It can affect newborns and (less commonly) fetuses; premature infants are at the greatest risk of neonatal encephalopathy which may lead to this condition. Affected individuals generally exhibit motor control problems or other developmental delays, and they often develop cerebral palsy or epilepsy later in life. The white matter in preterm born children is particularly vulnerable during the third trimester of pregnancy when white matter developing takes place and the myelination process starts around 30 weeks of gestational age. This pathology of the brain was described under various names ("encephalodystrophy", "ischemic necrosis", "periventricular infarction", "coagulation necrosis", "leukomalacia," "softening of the brain", "infarct periventricular white matter", "necrosis of white matter", "diffuse symmetrical periventricular leukoencephalopathy"), and more often by German scientists, but the worldwide dissemination was the term periventricular leukomalacia, introduced in 1962 B. A. Banker and J. C. Larroche. The term can be misleading, as there is no softening of the tissue in PVL. V. V. Vlasyuk and V. P. Tumanov in 1985 published the world's first monograph devoted to PVL. Vlasyuk (1981) first revealed the high incidence of optic radiation lesions and demonstrated that PVL - a persistent process that the old necrosis can join a new, foci of PVL may be at different stages of development. In the process of morphogenesis focuses PVL pass through three stages: 1) necrosis, 2) resorption, and 3) the formation gliosis scars or cysts. Cysts occur when large and confluent focuses of PVL, with mixed necrosis (kollikvacia in the center and coagulation rim at the periphery). Around the foci is generally defined area of other lesions of the brain white matter - the death of prooligodendrocytes, proliferation mikrogliocytes and astrocytes, swelling, bleeding, loss of capillaries, and others (the so-called "diffuse component PVL"). However, diffuse lesions without necrosis are not PVL. (en)
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