Mary Isenhour is an American political strategist, campaign manager, and government official. She was the Chief of Staff for Pennsylvania Governor Tom Wolf. Prior to the Wolf administration, Isenhour served executive director of the Pennsylvania Democratic Party, was state director of Hillary Clinton's 2008 presidential campaign, and assisted with the successful campaigns of U.S. Senator Bob Casey, Jr. and Pennsylvania Governor Ed Rendell. She now serves with the firm Rooney Novak Isenhour, LLC and is a member of the Pennsylvania Liquor Control Board.