María Odulio de Guzmán (born 1895) was a Filipino teacher, educator, principal, writer, and author. She was the first Filipino female principal of a secondary school in the Philippines. She worked as a teacher at the Nueva Écija High School in the province of Nueva Écija from 1918 to 1928. She graduated in 1930 from Radford State Teachers' College (now Radford University), located in Radford, Virginia, United States. She was a professor at the Philippine Normal College.