Manny Matsakis (born Emmanouel M. Matsakis; April 16, 1962) is an American football coach and former player. He was most recently the head football coach at Defiance College, a position he held from 2018 to 2021. Matsakis has also served as the head football coach at Emporia State University from 1995 to 1998, at Texas State University in 2003, and at Bethany College in Lindsborg, Kansas from 2013 to 2014.