Kathleen Marie Karpan (born September 1, 1942) is an American politician who served as secretary of state of Wyoming from 1987 to 1995, and as the director of the federal Office of Surface Mining Reclamation and Enforcement from 1997 to 2000. A member of the Democratic Party, she unsuccessfully ran for Wyoming's governor and United States senator as the Democratic nominee in 1994 and 1996, respectively.