James Churchwell Luttrell II (March 3, 1813 – July 6, 1878) was an American attorney and politician who served as Mayor of Knoxville, Tennessee, during the Civil War. His eight-year term (1859–1867) was the longest for any Knoxville mayor until the late 20th century, when it was surpassed by Victor Ashe's 16-year term. Luttrell also served as state comptroller in the late 1850s, and was elected to the state senate following his term as mayor.