Henry Lowndes Muldrow (February 8, 1837 – March 1, 1905) was an American politician who served as the First Assistant Secretary of the Interior in the first Cleveland administration. Prior to this he served as U.S. Representative from Mississippi's 1st congressional district, a member of the Mississippi House of Representatives and as an officer of the Confederate States Army who commanded a cavalry regiment in the Western Theater of the American Civil War. He was "Grand Cyclops" of the Oktibbeha County Ku Klux Klan den.