State Route 22 (SR 22) is a 221.1-mile-long (355.8 km) state highway that travels southwest-to-northeast in an eastern arc through portions of Muscogee, Talbot, Taylor, Upson, Crawford, Bibb, Jones, Baldwin, Hancock, Taliaferro, Oglethorpe, and Madison counties in the western and west-central parts of the U.S. state of Georgia. The highway connects the Alabama state line in Columbus, across the state line from Phenix City, Alabama, to Comer, via Macon and Milledgeville.