George Henderson Edmondson (May 18, 1896 – July 11, 1973) was an American professional baseball pitcher who appeared in eight games over parts of three Major League Baseball seasons (1922–1924) for the Cleveland Indians. The right-hander, nicknamed "Big Ed", was listed as 6 feet 1 inch (1.85 m) tall and 179 pounds (81 kg). He was born in Waxahachie, Texas. During his three brief trials with Cleveland, he posted a 0–0 won–lost record. In 14 innings pitched, he allowed 22 hits, eight bases on balls and 15 earned runs, for a career earned run average of 9.64.