The Frank R. Lillie House is a historic house at 5801 South Kenwood Avenue, on the campus of the University of Chicago on the South Side of Chicago, Illinois. Built in 1904 to a design by Pond and Pond, it was home for many years to Frank R. Lillie (1870–1947), a pioneering embryologist and influential supporter of the Woods Hole Oceanographic Institute. Designated a National Historic Landmark in 1976, it is now used by the university as office space.