Esperanza Alcantara Icasas-Cabral is a Filipino cardiologist and clinical pharmacologist. She served as Secretary of the Department of Health in the Philippines, taking office in January 2010 to replace Francisco Duque after his appointment as head of the Civil Service Commission. Before her appointment as Secretary of Health she was previously the Secretary of the Department of Social Welfare and Development, replacing Corazon Soliman. Cabral is married to Bienvenido Villegas Cabral, an ophthalmologist.