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About: Endothelin receptor antagonist     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : yago:WikicatEndothelinReceptorAntagonists, within Data Space : dbpedia.org associated with source document(s)

Type: yago:Adversary109773245yago:CausalAgent100007347yago:LivingThing100004258yago:Object100002684yago:Organism100004475yago:Person100007846yago:PhysicalEntity100001930yago:YagoLegalActoryago:YagoLegalActorGeodrugyago:Whole100003553yago:WikicatEndothelinReceptorAntagonists New Facet based on Instances of this Class

An endothelin receptor antagonist (ERA) is a drug that blocks endothelin receptors. Three main kinds of ERAs exist: * selective ETA receptor antagonists (sitaxentan, ambrisentan, atrasentan, BQ-123, zibotentan, ), which affect endothelin A receptors. * dual antagonists (bosentan, macitentan, tezosentan), which affect both endothelin A and B receptors. * selective ETB receptor antagonists (BQ-788 and A192621) which affect endothelin B receptors are used in research but have not yet reached the clinical trial stage.