The 527th Air Defense Group is a disbanded United States Air Force organization. Its last assignment was with the 4708th Air Defense Wing at Wurtsmith Air Force Base, Michigan. It was inactivated on 18 August 1955. The group was originally activated as a support unit for the 461st Bombardment Group at the end of World War II in Italy and then redeployed to the United States where it was inactivated in 1945.