The 2022 Houston Baptist Huskies softball team represented Houston Baptist University during the 2022 NCAA Division I softball season. The Huskies played their home games at Husky Field and were led by thirtieth year head coach Mary-Ellen Hall. They were members of the Southland Conference. This was the Huskies' final season as Houston Baptist. On September 21, 2022, the university announced it had adopted the new name of Houston Christian University. The Huskies nickname was not affected.