The 2021 Pittsburgh Panthers football team represented the University of Pittsburgh in the 2021 NCAA Division I FBS football season. The Panthers were led by seventh-year head coach Pat Narduzzi and played their home games at Heinz Field. They competed in the Atlantic Coast Conference (ACC). This was Pitt's ninth season as a member of the ACC. The Panthers won the ACC Championship with a record of 11–2 and a 45–21 victory over Wake Forest in the 2021 ACC Championship Game, becoming the first school other than Clemson or Florida State to win the conference championship since Virginia Tech in 2010.