The 2021 Arkansas State Red Wolves football team represented Arkansas State University in the 2021 NCAA Division I FBS football season. The Red Wolves played their home games at Centennial Bank Stadium in Jonesboro, Arkansas, and competed in the West Division of the Sun Belt Conference. Prior to the season, Arkansas State hired Butch Jones as head coach after Blake Anderson departed for Utah State. The team announced Rob Harley as their new defensive coordinator shortly after Jones' arrival.