The 2021–22 Seton Hall Pirates men's basketball team represented Seton Hall University in the 2021–22 NCAA Division I men's basketball season. They were led by 12th-year head coach Kevin Willard. The Pirates played their home games at the Prudential Center in Newark, New Jersey and Walsh Gymnasium in South Orange, New Jersey as members of the Big East Conference. They finished the season 21–11, 11–8 in Big East play to finish a tie for fifth place. They defeated Georgetown in the first round of the Big East tournament before losing in the quarterfinals to UConn. They received an at-large bid to the NCAA tournament as the No. 8 seed in the South region where they lost in the first round to TCU.