The 2020–21 South Florida Bulls men's basketball team represented the University of South Florida during the 2020–21 NCAA Division I men's basketball season. The season marked the 49th basketball season for USF, the eighth as a member of the American Athletic Conference, and the fourth season under head coach Brian Gregory. The Bulls play their home games at Yuengling Center on the university's Tampa, Florida campus. The season ended on March 12, 2021 with a 68–67 loss to regular season conference champion Wichita State in the second round of the AAC tournament.