The 2018–19 Southern Miss Golden Eagles men's basketball team represented the University of Southern Mississippi during the 2018–19 NCAA Division I men's basketball season. The Golden Eagles, led by fifth-year head coach Doc Sadler, played their home games at Reed Green Coliseum in Hattiesburg, Mississippi as members of Conference USA. They finished the season 20-13, 11-7 in C-USA Play to finish a 2-way tie for 2nd place. They defeated Marshall in the quarterfinals of the C-USA tournament before losing in the semifinals to Western Kentucky. They received an at-large bid to the College Basketball Invitational where they lost in the first round to Longwood.