The 2018–19 High Point Panthers women's basketball team represents High Point University during the 2018–19 NCAA Division I women's basketball season. The Panthers, led by seventh-year head coach DeUnna Hendrix, play their home games at the Millis Athletic Convocation Center as members of the Big South Conference. They finished the season 22–9, 15–3 in Big South play to finish in second place. They lost in the quarterfinals of the Big South women's tournament to Charleston Southern. They received an automatic bid to the WNIT where they lost to Ohio in the first round