The 2017–18 USC Upstate Spartans women's basketball team represents the University of South Carolina Upstate in the 2017–18 NCAA Division I women's basketball season. The Spartans, led by thirteenth year head coach , play their games at G. B. Hodge Center and were members of the Atlantic Sun Conference. They finished the season 11–19, 6–8 in A-Sun play to finish in fifth place. They lost in the quarterfinals of to Lipscomb.