The 2017–18 Southern Miss Lady Eagles basketball team represents the University of Southern Mississippi during the 2017–18 NCAA Division I women's basketball season. The Lady Eagles, led by fourteenth year head coach , play their home games at Reed Green Coliseum and were members of Conference USA. They finished the season 15–15, 7–9 in C-USA play to finish in a 3 way tie for seventh place. They lost in the first round of the C-USA women's tournament to UTEP.