The 2017–18 Missouri State Lady Bears basketball team represented Missouri State University during the 2017–18 NCAA Division I women's basketball season. The Lady Bears, led by fifth year head coach Kellie Harper, played their home games at JQH Arena and were members of the Missouri Valley Conference. They finished the season 21–12, 15–3 in MVC play to finish in second place. They advanced to the semifinals of the Missouri Valley Tournament where they lost to Northern Iowa. They received an automatic bid to the Women's National Invitation Tournament where defeated Louisiana Tech in the first round before losing to TCU in the second round.