The 2012 United States Senate election in Missouri was held on November 6, 2012, concurrently with the 2012 presidential election, other elections to the United States Senate in other states, as well as elections to the United States House of Representatives and various state and local elections. Incumbent U.S. Senator Claire McCaskill was unopposed in the Democratic primary and U.S. Representative Todd Akin won the Republican nomination with a plurality in a close three-way race. McCaskill was re-elected to a second term. As of 2022, this was the last time the Democrats won a U.S. Senate election in Missouri.