The 2010 San Francisco 49ers season was the franchise's 65th season, their 61st in the National Football League, and the third year with Mike Singletary as the head coach. The 49ers were looking to build upon their 8–8 season in 2009.
La stagione 2010 dei San Francisco 49ers è stata la 61ª della franchigia nella National Football League. Tentando di migliorare il record di 8-8 dell'anno precedente, la squadra iniziò però con un pessimo record di 0–5, terminando con un bilancio di 6-10. A una gara dal termine della stagione, l'allenatore Mike Singletary fu licenziato. (it)
The 2010 San Francisco 49ers season was the franchise's 65th season, their 61st in the National Football League, and the third year with Mike Singletary as the head coach. The 49ers were looking to build upon their 8–8 season in 2009. (en)