The 2005–06 Creighton Bluejays men's basketball team represented Creighton University in the 2005–06 NCAA Division I men's basketball season. Led by head coach Dana Altman in his 12th season, the Bluejays would end the season with a record of 20–10 (12-6 MVC). They qualified for the NIT where they defeated Akron before losing to Miami (FL) in the second round.