The 2001 Michigan State Spartans football team represented Michigan State University in the 2001 NCAA Division I-A football season. The Spartans played their home games at Spartan Stadium in East Lansing, Michigan. This was the second year for head coach Bobby Williams, who led the Spartans to a 7-5 record including a 44–35 victory in the 2001 Silicon Valley Football Classic over the Fresno State Bulldogs of the Western Athletic Conference.