The 1978–79 San Francisco Dons men's basketball team represented the University of San Francisco as a member of the West Coast Athletic Conference during the 1978–79 NCAA Division I men's basketball season. The Dons opened the season with a top 20 ranking, but fell out after a couple early season losses. San Francisco battled back to finish the season with a 22–7 record (12–2 WCAC) and a No. 12 ranking in the final AP poll. As champions of the West Coast Athletic Conference, San Francisco played in the NCAA Tournament as No. 4 seed in the West region. To date, this season marks the most recent time the Dons have reached the Sweet Sixteen.