The 1957 Wyoming Cowboys football team represented the University of Wyoming in the Skyline Conference during the 1957 NCAA University Division football season. In their first season under head coach Bob Devaney, the Cowboys compiled a 4–3–3 record (3–2–2 against Skyline opponents), finished fourth in the Skyline Conference, and outscored all opponents by a total of 139 to 135. The 1957 season was Bob Devaney's first as a head coach. He was later inducted into the College Football Hall of Fame