The 1946 Ole Miss Rebels football team was an American football team that represented the University of Mississippi in the Southeastern Conference (SEC) during the 1946 college football season. In their first year under head coach Harold Drew, the Rebels compiled a 2–7 record (1–6 against SEC opponents) and were outscored by a total of 144 to 76. Two Ole Miss player ranked among the national leaders. Charlie Conerly ranked sixth nationally with 641 passing yards. End Barney Poole ranked fifth nationally with 28 pass receptions.