The 1899 Sewanee Tigers football team represented Sewanee: The University of the South in the 1899 Southern Intercollegiate Athletic Association football season. Sewanee was one of the first college football powers of the South and the 1899 team was one of its best. The 1899 Tigers won 12 games and lost none, outscored opponents 322–10, and won the Southern Intercollegiate Athletic Association (SIAA) title.